Press tofu for 15 minutes to remove excess moisture, then cut into 1-inch cubes.
In a small bowl, whisk together tamari, sesame oil, rice vinegar, minced ginger, and minced garlic to create the sauce.
Heat avocado oil in a large non-stick skillet or wok over medium-high heat.
Add tofu cubes to the pan and sear until golden brown and crispy on all sides, about 8-10 minutes.
Add broccoli florets, sliced red bell pepper, and edamame to the skillet with the tofu.
Stir-fry the vegetables for 4-5 minutes until the broccoli is tender-bright green but still has a bite.
Pour the sauce over the tofu and vegetables, tossing quickly to coat everything evenly as the sauce thickens slightly.
Remove from heat and garnish with sesame seeds and red pepper flakes before serving.