In a medium bowl, combine the ground chicken, sea salt, black pepper, garlic powder, and onion powder.
Gently mix the ingredients by hand until just combined, being careful not to overwork the meat.
Form the mixture into one large, thick patty, approximately 1-inch thick.
Heat the olive oil in a non-stick skillet over medium heat until shimmering.
Place the patty in the skillet and cook for 5 to 6 minutes per side, or until the internal temperature reaches 165°F.
While the chicken cooks, wash and pat dry the butter lettuce leaves to use as your wrap.
Slice the avocado, tomato, and red onion.
Place the cooked chicken patty onto the lettuce leaves and top with the tomato, onion, and creamy avocado slices.