Peel and dice the sweet potato into 1/2-inch cubes and chop the chicken breast into bite-sized pieces.
Heat the avocado oil in a large cast-iron skillet over medium-high heat until shimmering.
Add the sweet potato cubes to the skillet and cook for 8-10 minutes, stirring occasionally, until they begin to soften and develop golden edges.
Push the potatoes to the side of the pan and add the chicken pieces to the center.
Sprinkle the smoked paprika, garlic powder, sea salt, and black pepper over the chicken and potatoes.
Add the broccoli florets, sliced bell peppers, and diced red onion to the skillet.
Sauté everything together for another 6-8 minutes, stirring frequently, until the chicken is cooked through and the vegetables are crisp-tender.
Remove from heat and serve immediately while hot.