Place a large skillet over medium-high heat and add the ground beef, breaking it apart with a wooden spoon or spatula.
Cook the beef until fully browned and no pink remains, then drain any excess liquid from the pan.
Stir in the chili powder, ground cumin, garlic powder, sea salt, and black pepper, tossing the meat until evenly coated in the spices.
In a large serving bowl, create a base with the chopped romaine lettuce.
Top the lettuce with the seasoned ground beef, halved cherry tomatoes, diced red bell pepper, and finely diced red onion.
Garnish the bowl with fresh avocado slices and chopped cilantro.
Drizzle the fresh lime juice over the entire salad just before serving to brighten the flavors.