In a small bowl, whisk together the Greek yogurt, mustard, pickle juice, and half of the garlic powder, onion powder, and paprika to create the creamy special sauce.
Heat a non-stick skillet over medium-high heat and add the ground beef, seasoning it with the remaining garlic powder, onion powder, paprika, sea salt, and black pepper.
Cook the beef until browned and fully cooked through, breaking it into small crumbles with a spatula.
Assemble the bowl by placing the shredded romaine lettuce at the bottom.
Top the lettuce with the warm seasoned beef, shredded cheddar cheese, diced onions, and diced pickles.
Drizzle the prepared special sauce over the bowl and garnish with sesame seeds for a nutty crunch.