Bring a large pot of salted water to a boil and cook the whole wheat penne according to package directions until al dente.
While the pasta cooks, slice the chicken breast into thin strips and season with sea salt and black pepper.
Heat the ghee in a large skillet over medium-high heat. Add the chicken and sear until golden brown and cooked through, then remove from the pan and set aside.
In the same skillet, add the sliced cremini mushrooms and sauté until they release their moisture and turn a deep brown.
Add the minced garlic to the mushrooms and cook for 30 seconds until fragrant.
Drain the pasta, reserving two tablespoons of the cooking water.
Return the chicken to the skillet with the mushrooms, then add the cooked pasta and reserved pasta water.
Toss everything together over low heat, then remove from the burner.
Drizzle with truffle oil and sprinkle with parmesan cheese and fresh chopped parsley before serving.