Press the tofu for at least 15 minutes to remove excess moisture, then cut into 1-inch cubes.
In a small bowl, whisk together the tamari, honey, toasted sesame oil, minced ginger, minced garlic, and red pepper flakes to create the glaze.
Heat the avocado oil in a large non-stick skillet or wok over medium-high heat.
Add the tofu cubes to the skillet and sear until golden brown and crispy on all sides, approximately 8 to 10 minutes.
Add the broccoli florets and shelled edamame to the skillet, sautéing for 4 to 5 minutes until the broccoli is tender-crisp and bright green.
Pour the garlic-ginger glaze over the tofu and vegetables, tossing constantly for 1 to 2 minutes until the sauce thickens and coats all ingredients evenly.
Remove from heat, garnish with sesame seeds, and serve immediately.