Preheat your oven to 400°F (200°C) and line a large rimmed sheet pan with parchment paper for easy cleanup.
In a small glass jar or bowl, whisk together the honey, tamari, minced garlic, and olive oil until the glaze is fully emulsified.
Place the cubed chicken breast, diced sweet potatoes, and halved Brussels sprouts onto the prepared sheet pan.
Sprinkle the sea salt, black pepper, and smoked paprika over the ingredients, then drizzle with the honey-garlic glaze.
Use your hands or tongs to toss everything together until every piece is well-coated in the savory sauce.
Spread the mixture into a single even layer, ensuring the chicken pieces are not touching to allow for proper browning and caramelization.
Roast in the center of the oven for 22 to 25 minutes, tossing halfway through, until the chicken is cooked to 165°F and the veggies are tender.