Preheat your oven to 400°F and line a large sheet pan with parchment paper for easy cleanup.
Prepare the vegetables by halving the Brussels sprouts, trimming the woody ends from the asparagus, and slicing the peppers and onions into thin strips.
Place the chicken tenderloins, Brussels sprouts, asparagus, peppers, onions, and cherry tomatoes onto the prepared sheet pan.
Drizzle the olive oil over the chicken and vegetables, then sprinkle evenly with the garlic powder, onion powder, sea salt, black pepper, and smoked paprika.
Toss all ingredients together on the pan until everything is well-coated in the oil and spices, then spread them out into a single layer.
Roast for 18 to 22 minutes, or until the chicken is cooked through and the vegetables are tender with slightly crispy, charred edges.